Abstract
Autologous bone remains the gold standard grafting substrate for bone fusions used for small gaps and critical defects. However, significant morbidity is associated with the harvesting of autologous bone grafts and, for that reason, alternative bone graft substitutes have been developed. In the present case series, a glass-reinforced hydroxyapatite synthetic bone substitute, with osteoinductive and osteoconductive proprieties, was applied. This synthetic bone substitute comprises the incorporation of P2O5-CaO glass-based system within a hydroxyapatite matrix, moulded into spherical pellets with 250-500 μm of diameter. A total of 14 veterinary clinical cases of appendicular bone defects and maxillary / mandibular bone defects are described. In all clinical cases, the synthetic bone substitute was used to fill bone defects, enhancing bone regeneration and complementing the recommended surgical techniques. Results demonstrated that it is an appropriate synthetic bone graft available to be used in veterinary patients. It functioned as a space filler in association with standard orthopaedic and odontological procedures of stabilization, promoting a faster bone fusion without any local or systemic adverse reactions. This procedure improves the animals’ quality of life, decreasing pain and post-operative recovery period, as well as increasing bone stability improving positive clinical outcomes.
Highlights
With increasing average life expectancy [1] the number of degenerative diseases, osteogenic disorders and bone fractures has scaled in recent decades [2]
Between the years of 2017 and 2018, the described veterinary clinical applications were performed in 10 canine and 4 feline patients, aged from 1 to 16 years
These surgical procedures included Bonelike® grafting on defects after mandibular fractures with loss of bone and/or mandibular and maxillary tooth extractions (8 canine and 4 feline patients)
Summary
With increasing average life expectancy [1] the number of degenerative diseases, osteogenic disorders and bone fractures has scaled in recent decades [2]. Bone defects due to trauma, pathological and physiological bone resorption represent a major challenge and are a global health problem [3], in both human and domestic animal individuals. The traditional methods for repairing bone defects (such as autografts, allografts and xenografts). Campos et al Biomaterials Research (2018) 22:38 demonstrated that hydroxyapatite bioactivity is improved through the combination with a P2O5-CaO-Na2O glass system (resulting biomaterial patented as Bonelike®) [8]. Bonelike® is composed by a modified hydroxyapatite (HA) matrix, with α- and β-tricalcium phosphate secondary phases, that counterpart HA’s brittle and essentially non-degradable character, improving the bioresorption of the modified system [9]. The mechanical properties of the temporary graft are improved by the CaO-P2O5 based glasses [12, 13]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
