Abstract
Objectives:The paper uses block matching method combined with echocardiography to explore the value of N-terminal pro-brain natriuretic peptide (NT-proBNP) in predicting symptomatic patent ductus arteriosus (PDA) in preterm infants.Methods:We selected premature infants born between February 2019 and March 2020, gestational age ≤32 weeks, and echocardiography within 48 hours to determine the presence of arterial ducts as the research object, monitor their clinical manifestations, and detect serum at three and five days after birth The level of NT-proBNP was checked with echocardiography, and the children were divided into PDA group and asymptomatic patent ductus arteriosus (aPDA) group according to the clinical manifestations and echocardiographic.Results:The area under the ROC curve of PDA predicted by serum NT-proBNP level at 3 days after birth was 0.949, the cut-off value was 27035pg/mL, the sensitivity was 92.3%, and the specificity was 94.6%; serum NT-proBNP level at 5 days after birth predicted the ROC curve of PDA The lower area is 0.924, the critical value is 6411 pg/mL, the sensitivity is 92.3%, and the specificity is 92.9%.Conclusion:NT-proBNP may be a quantitative indicator of arterial duct shunt; the detection of serum NT-proBNP levels at 3 and 5 days after birth is helpful for early prediction of PDA.
Highlights
Patent ductus arteriosus (PDA) is one of the common complications of preterm infants and it is important to predict the emergence of PDA early [1]
The results showed that the level of NT-proBNP in neonatal serum was positively correlated with the diameter of ductus arteriosus and the ratio of LA/AO, which was similar to the research results of Alenazi.[9]
These results suggested that neonatal serum NTproBNP level can better reflect the changes of cardiac volume load than clinical symptoms, and may be a quantitative indicator of arterial shunt, which can reflect the hemodynamic changes of neonates with PDA
Summary
Patent ductus arteriosus (PDA) is one of the common complications of preterm infants and it is important to predict the emergence of PDA early [1]. Echocardiography is the gold standard for diagnosing PDA, but the equipment is expensive and cannot be widely used in primary hospitals [2]. This study prospectively analyzed the clinical course of premature infants with PDA, while studying the correlation between NT-proBNP and echocardiographic indicators, as well as the sensitivity and specificity of NTproBNP in predicting PDA, and exploring the clinical value of early NT-proBNP levels in predicting PDA. Pak J Med Sci September 2021 (Speical Issue Online) Vol 37 No 6 www.pjms.org.pk 1657
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