Abstract
Liver toxicity is a key reason why new drugs fail in clinical trials, or once they are in broader use. Drug-induced cholestasis is a common form of liver toxicity. Yet currently there is no model or test to predict which drugs may induce cholestasis in patients.This report demonstrate how bioinformatics approach on the example of using Elsevier's Pathway Studio® pathway analysis software can be used to create complex, predictive mechanistic models of biological processes, providing novel insights to researchers and helping them direct the course of their studies. The report will highlight application of bioinformatics and mechanistic models approach to biomarkers research. Presented examples include following: prediction of biomarkers based on reconstructed liver toxicity model, identification of new potential candidates for drug targets, identification of drug efficacy biomarkers or safety biomarkers and assessment of clinical biomarker specificity.
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