Abstract
There are several basophil activation and degranulation markers for basophil activation test discovered in recent years. However, only CD63 and CD203c are actively used. The activation and degranulation markers (CD11b, CD13, CD63, CD69, CD107a, CD164, CD203c and CD300a) were characterized from the point of view of the possibility to use for BAT and their clinical efficiency. It has been shown that the degranulation marker CD107a and the activation marker CD11b have high sensitivity and specificity and can be used to diagnose hypersensitivity to pollen allergens.
Highlights
Цель исследования – изучить чувствительность и специфичность маркеров активации и дегрануляции базофилов для диагностики IgE-опосредованной гиперчувствительности к пыльце тимофеевки
There are several basophil activation and degranulation markers for basophil activation test discovered in recent years
The activation and degranulation markers (CD11b, CD13, CD63, CD69, CD107a, CD164, CD203c and CD300a) were characterized from the point of view of the possibility to use for BAT and their clinical efficiency
Summary
Цель исследования – изучить чувствительность и специфичность маркеров активации и дегрануляции базофилов для диагностики IgE-опосредованной гиперчувствительности к пыльце тимофеевки. В. Применение маркеров активации и дегрануляции базофилов для диагностики пыльцевой аллергии / И. ROC-кривые чувствительности и специфичности маркеров активации и дегрануляции базофилов ROC-curves of sensitivity and specificity of basophil activation and degranulation markers
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