Abstract
In the pharmaceutical industry, controlling the crystallization process of active pharmaceutical ingredients (API) is crucial to ensure chemical quality and physical properties. Process analytical technologies (PAT) provide a large number of tools that provide information in real-time to allow mastery of the final solid chain. In this paper is described how attenuated total reflection ultraviolet (ATR-UV) spectroscopy can be used to monitor concentration. Besides its classical application to UV-absorbing molecules, it will be shown how, in principle, it may be applied to molecules that do not absorb at UV wavelengths.
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