Abstract
Fertilization failure is a serious challenge of assisted reproduction treatment especially for intracytoplasmic sperm injection (ICSI) cycles, in recent years, artificial oocyte activation (AOA) technology had shined a light on this problem. But the mechanism of oocyte activation failure is still a lack of clear research, as AOA cannot recover all types of fertilization failure, the clinical indications and safety of AOA is still the focus of attention. Although the current study did not show the AOA technology could significantly increase their offspring birth defects, this technology should be cautiously used for selected cases with appropriate indications.This article summarized recent progress of mechanisms and types of ICSI fertilization failure, also the application of AOA and its safety, hoping to give a general view of AOA technique for the ART clinicians and embryologists. Key words: Intracytoplasmic sperm injection (ICSI); Fertilization failure; Artificial oocyte activation (AOA)
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