Application of antibiotic beads in the treatment of chronic osteomyelitis

Abstract

Objective To investigate the clinical effect of antibiotic beads in the treatment of chronic osteomyelitis.Methods 18 patients with chronic osteomyelitis who had received focus debridement were randomly divided into observation group (12 cases) and control group (9 cases).Control group continued postoperative systemic antibiotic treatment,and observation group used antibiotic beads to fill dead space on the basis of control group.Compared and analyzed the clinical effect of two groups after 3 weeks.Results In observation group,fractures of 12 cases were all at or near anatomic reduction and healed,with 11 cases of Phase Ⅰ fracture healing; 1 cases recurred 6 months later,received debridement and antibiotic beads implantation,then recovered; the total effective rate was 100％,without serious adverse reaction during follow-up.In control group,3 cases were cured,2 cases were improved,4 cases were ineffective,with the total effective rate of 55.56％; 1 case of pin track infection recovered after symptomatic treatment.There was significant difference between two groups (x 2=7.283,P ＜ 0.01).Conclusions Topical application of antibiotics beads filling treatment has advantages such as high topical antibiotic concentration,slow release,long lasted time,comfort for patients,faster wound closure,shorter hospitalization time,low cost and less adverse reaction,which is an ideal method in the treatment of chronic osteomyelitis,worthy of clinical application. Key words: Chronic osteomyelitis; Antibiotic beads; Clinical efficacy