Application of analytical Eco-Scale and Complex-GAPI tools for green assessment of a new simple nanoparticle modified carbon paste electrode method for voltammetric determination of mosapride citrate in pharmaceutical dosage form and human plasma

Abstract

A new, sensitive, eco-friendly and reliable electrochemical method was reported for determination of mosapride citrate (MOS). The method is based on the electrochemical oxidation of MOS after modification of carbon paste electrode (CPE) with 2% zirconium oxide (ZrO2) and cationic surfactant cetrimide using differential pulse voltammetry in 0.2 M phosphate buffer pH 5. Different instrumental and experimental parameters involved in the electrochemical determination were studied and optimized, including pH, buffer type and its concentration, and scan rate. The studied nanoparticles modified CPE showed high sensitivity and excellent anodic response with a linear relationship between the peak current and the molar concentration of the studied drug over the concentration range of 0.08–1.48 μM (equivalent to 0.05–0.91 μg mL−1). The limits of detection and quantification were found to be 0.01 and 0.08 μM, respectively. The proposed method was successfully applied for the determination of MOS in authentic drug, tablet dosage form and spiked human plasma. The proposed method was validated according to ICH guidelines showing high accuracy and precision with recovery100.04% and RSD 1.21%. The results of the analysis obtained showed a good agreement with those obtained from the reported method.