Abstract
A formal total synthesis of natural (−)-epibatidine has been developed. Key steps in the synthesis are a copper(I)-mediated coupling of an ( S)-pyroglutamic acid-derived organozinc reagent with 1-iodo-3-trimethylsilyl-1-propyne and an N-acyl- or N-sulfonyliminium ion cyclization. Following this route, various N-protected hydroxylactams were converted into 7-azabicylo[2.2.1]heptane derivatives.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
