Abstract
The emergence of SARS-CoV-2 is the third introduction of a highly pathogenic coronavirus into the human population after the severe acute respiratory syndrome coronavirus (SARS-COV) and the Middle East respiratory syndrome coronavirus (MERS-COV). Even after taking thousands of human lives, there is no effective curative treatment till date. This virus infects human body by means of aerosol, droplets and contact. Mucous membrane mainly respiratory epithelium is the point of entry in case of SARS-COV2. Then it fuses with the pneumocytes and macrophages of respiratory epithelium by a complex protein-protein interaction. And this initial vital process of fusion needs acidic micro-environment. Here I propose a novel therapeutic approach that can prevent the entry of the virus into host cell and thus will curb down the infection rate and its severity significantly. Moderate alkaline solution of sodium bicarbonate will be used by a nebulizer, rotahaler or inhaler to the respiratory tract to make the airway surface fluid alkaline from acidic and this will hinder the entry of virus to host cells.
Highlights
1 BACKGROUND INFORMATION: Corona virus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) with aerosol, droplets and contact as the main means of transmission .From the appearance of first case in wuhan, China in December,2019, it has become a pandemic
For successful infection they need to deliver their nucleocapsid into the host cell for which they rely on the fusion of their envelope with the host cell membrane by a complex protein-protein interaction that demands a low pH status in respiratory epithelium [1, 2]
I propose the use of alkaline solution through an inhaler or nebulizer and this will effectively disturb the pH of the local micro-environment, which will be enough to resist viral fusion with host cell
Summary
Every country is facing the challenge of this menace as covid-19 has a high secondary attack rate. It needs an effective preventive and curative measure. SARS-COV-2 are enveloped positivestranded RNA viruses that replicate in the cytoplasm. For successful infection they need to deliver their nucleocapsid into the host cell for which they rely on the fusion of their envelope with the host cell membrane by a complex protein-protein interaction that demands a low pH status in respiratory epithelium [1, 2]. PH of LLF lies within a mildly alkaline range of 7.5–8.2 [4]. Iii) Evaluating the infectivity of COVID -19 patients by swab collection from nasopharynx and oropharynx after alkaline solution treatment
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