Abstract
The development of analytical techniques for estimation of free drug concentration is crucial for the needs of modern pharmacology. Up to now, many different methods of free drug assay have been used. The methods involving isolation of free drug from a sample are most frequently applied because they can be easily adopted for the processing of real samples. Among the methods that do not require free drug isolation only the adsorption method could be promising in application to samples of this kind. The successful use of the adsorption method is possible only if two requirements are fulfilled: (I) the chosen adsorbent does not bind proteins from the sample and (II) the processes of adsorption of the assayed drug on the adsorbent used and on the protein should be independent. This paper discusses the possibilities of application of the adsorption method for determination of free drug concentration using propofol as the model drug. The presented results show that the fulfillment of the above conditions may be very difficult if not impossible not only for propofol, but for other drugs as well.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
