Abstract
Objective To investigate the significance of adenosine-triphosphate (ATP) value of CD4+ T cells and T cell subset analysis in monitoring immune function after liver transplantation.Methods Immuknow immune cell function kit was applied to test the ATP value of CD4 + T cells in peripheral blood from 48 patients undergoing liver transplantation and 30 healthy volunteers.Additionally,the frequency of CD3+,CD4+ and CD8+ cell subsets was analyzed by flow cytometry.Results For healthy volunteers,stable recipients,infectious recipients and recipients with acute rejection,the mean ATP levels were (331 ± 103),(364 ± 125),(182 ± 104) and (479 ± 116) μg/L,respectively.The ATP levels in acute rejection patients were higher than stable ones (P ＜ 0.01) and patients with infections (P ＜ 0.01).However,there was no statistically significant difference between stable recipients and recipients with acute rejection (P ＞ 0.05).T cell subsets analysis showed that the CD4+ cell counts were (25.53 ± 6.89) ％ in the infectious patients and (33.23 ± 11.34) ％ in stable group,there was a significantly different in two groups (P ＜ 0.05).Conclusion The ATP levels in CD4+ T cells and T cell subsets analysis can indicate the immune status after liver transplantation to a certain extent. Key words: Liver transplantation; CD4+ T cell; Lymphocyte subsets ; Immune
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