Application of a free volume model in correlating thermodynamic properties of β-lactam, tetracycline, fluoroquinolone and chloramphenicol antibiotic groups in associating fluids

Abstract

In this work, an expression for the free volume Gibbs energy model based on the local composition concept (LCC) has been proposed in correlating the solubility, the partitioning and the surface tension of β-lactam, tetracycline, fluoroquinolone and chloramphenicol antibiotic groups in water, alcohol, ketone, trihalomethane, ether and ester solvent groups. Similar to the LCC models the proposed model has two combinatorial and residual terms. The extended Guggenheim model is used as combinatorial term and a new local composition-based model, which is the extended local area fraction NRTL-NRF model, is proposed for the residual term. The results obtained from the proposed model have been compared with those obtained from the UNIQUAC and the UNIQUAC-NRF models. Also, the proposed model has been developed in obtaining the surface tension of β-lactam, antibiotic groups in aqueous solutions. It has been concluded that the results of the proposed model can more accurately correlate the solubility, the partitioning and the surface tension of β-lactam, tetracycline, fluoroquinolone and chloramphenicol antibiotic groups in water, alcohol, ketone, trihalomethane, ether and ester solvent.