Abstract
The purpose of this investigation is the coating of powders in a fluidised bed. A 2n factorial design is developed in order to find the experimental conditions with the greatest influence on the quality of the coating. Therefore experiments are performed on lactose 80 mesh, taken as a model substance, with cellulose acetate phthalate as the coating material. Five factors are investigated at two levels. From the experiments the factors and interactions having a significant effect can be selected: the temperature of the inlet air, the concentration of the coating solution, the addition of talc as a filler to the coating solution and the interactions between spraying pressure-spraying rate and between spraying pressure-concentration. The fluidised bed technique is then applied to the coating of four drugs which need different coatings. For carnidazol an enteric coated granulation is required. Ferrous aspartate has to be protected from oxidation. Piracetam and etabenzarone hydrochloride require a taste masking coating. The results illustrate well the usefulness of the preliminary factorial design.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
