Abstract

BackgroundA reliable biomarker to identify cortical tissue responsible for generating epileptic seizures is required to guide prognosis and treatment in epilepsy. Combined spike ripple events are a promising biomarker for epileptogenic tissue that currently require expert review for accurate identification. This expert review is time consuming and subjective, limiting reproducibility and high-throughput applications. New methodTo address this limitation, we develop a fully-automated method for spike ripple detection. The method consists of a convolutional neural network trained to compute the probability that a spectrogram image contains a spike ripple. ResultsWe validate the proposed spike ripple detector on expert-labeled data and show that this detector accurately separates subjects with low and high seizure risks. Comparison with Existing MethodThe proposed method performs as well as existing methods that require manual validation of candidate spike ripple events. The introduction of a fully automated method reduces subjectivity and increases rigor and reproducibility of this epilepsy biomarker. ConclusionWe introduce and validate a fully-automated spike ripple detector to support utilization of this epilepsy biomarker in clinical and translational work.

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