Abstract
Three dimensional printed open port probe (3DP-OPP) and air displacement based liquid handler, were designed and optimized using fused deposition modeling (FDM) and stereolitography (SLA) 3D printing. The performance of the devices were investigated for the analysis of solid and liquid samples with electrospray ionization mass spectrometry (ESI-MS). Direct analysis in less than 1 min and without any sample preparation, enabled detection of pesticides (azoxtystrobin/imazalil) on fruits peel surface and illegal substances (MDMA/MDEA) in home-made pills. Conjunction of OPP in the overspill mode with a customized autosampler, equipped with disposable pipette tips, enables direct quantitative analysis of drugs of abuse in urine and plasma, with minimized carry-over and reduced matrix effect compared to flow injection analysis.
Highlights
Three dimensional printing (3DP) enables “creation” of the virtual objects into physical form using computer-aided drawing (CAD) files
The performance of the devices were investigated for the analysis of solid and liquid samples with electrospray ionization mass spectrometry (ESI-MS)
Simple in design interface, that can be used with mass spectrometry ionization sources based on nebulizing gas, for instance electrospray ionization (ESI) or atmospheric pressure chemical ionization (APCI)
Summary
Three dimensional printing (3DP) enables “creation” of the virtual objects into physical form using computer-aided drawing (CAD) files. We applied 3DP for redesigning and optimizing sampling interfaces, such as the described by Van Berkel open port probe (OPP) [19] It is a versatile, simple in design interface, that can be used with mass spectrometry ionization sources based on nebulizing gas, for instance electrospray ionization (ESI) or atmospheric pressure chemical ionization (APCI). Simple in design interface, that can be used with mass spectrometry ionization sources based on nebulizing gas, for instance electrospray ionization (ESI) or atmospheric pressure chemical ionization (APCI) It enables rapid introduction of samples by direct contact with sampling dome – a region where solvent is freely delivered and simultaneously aspirated into ionization source. Validated methods of analyzing illegal drugs in urine and minimally processed plasma, are described
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