Abstract
Objective To summarize our experience of application of intraoperative magnetic resonance imaging (iMRI) in glioma surgery and to investigate its clinical efficiency. Methods A retrospective analysis was conducted to evaluate the extent of resection (EOR) and outcomes of 366 glioma patients who underwent craniotomy under guidance of iMRI from December 2010 to December 2016 at Department of Neurosurgery, Huashan Hospital, Fudan University. Regular follow-up and head MRI were performed for all patients. Overall survival (OS) and progression free survival (PFS) curves were analyzed by Kaplan-Meier method. Log-rank tests and Cox proportional hazards model were used for univariate and multivariate comparisons, respectively. Results A total of 366 glioma patients were enrolled into this study. The rate of gross total resection (GTR) was 67.2%. The GTR rate of glioblastoma multiform (GBM) (73.2%) was significantly higher than that of grade Ⅱ (58.5%, P 0.05). Following the initial iMRI scan, 90 patients underwent further resection with a significant improvement of mean EOR from 81.9% to 95.9% (P 0.05). Conclusion The application of iMRI could efficiently increase the EOR of glioma surgery and improve the prognosis of glioma patients. Key words: Glioma; Magnetic resonance imaging; Neurosurgical procedures; Prognosis
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