Application of "30-60-90” rule in neonatal oxygen therapy

Abstract

Objective To observe the change of relevant indicators in titrating neonatal fraction of inspired oxygen(FiO2) for the target SpO2 according to the “30-60-90” rule.Methods 100 neonates with anoxia neonatorum were randomly selected and divided into premature group (50 cases) and mature group (50 cases).Pulse oximeter was used to monitor the pulse oximetry saturation (SpO2) and “30-60-90” rule was used to titrate FiO2 for the target SpO2.Blood gas was analyzed half an hour after the SpO2 was stable.The success rate was calculated and double variables were used to analyze the value of arterial oxygen tension (PaO2),SpO2 and arterial oxygen saturation (SaO2) statistically.Results The success rate to reach the target range of PaO2 was 90％,in which the premature group was 92％ and the mature group was 88％.According to the correlation analysis,there was positive correlation between SpO2 and SaO2 in premature group (r =0.765,P =0.000) and mature group (r =0.778,P =0.000),and between SpO2 and PaO2 in premature group (r =0.593,P =0.000) and mature group(r =0.726,P =0.000).The SpO2 and PaO2 of the premature group were lower than that of the mature group,and the differences were statistically significant (Z =-3.175,-2.409,respectively; P ＜ 0.05).There was no significant difference of PaO2,however,between the premature group and the mature group (P ＞ 0.05).Conclusions The “30-60-90” rule is a very convenient and effective bedside guideline for neonatal oxygen therapy,which is worthy in clinical promotion and implementation. Key words: Infant, newborn ; “30-60-90” rule ; Oxygen therapy ; Pulse arterial oxygen saturation; Arterial blood oxygen partial pressure