Abstract

Besides the study and the medical application of iron oxide nanoparticles, ferrites produced with zinc and manganese are of particular interest for their properties. The introduction of these elements into the crystalline structure of the magnetic particle generates some changes in the material properties, enhancing their potential use in theranostic applications. This review will cover the most important aspects of the preparation of these materials, taking into account the different methods of synthesis, and will analyze the most promising results in their use in MRI, magnetic hyperthermia and other emerging applications.

Highlights

  • Over the past years, the field of nanotechnology has exploited the improved novel physical, chemical and biological properties of materials at the nanometric scale

  • Magnetic nanoparticles have been exploited in intracellular magnetic hyperthermia, in novel photothermic treatments, in magnetic resonance imaging (MRI), in Magnetic Particle Imaging (MPI), in magnetic-guided drug delivery, in integrated biosensors and in bio-separations [6,7]

  • This review will focus on the applications of Mn-Zn ferrite NPs in biomedical applications, by covering the most important aspects of the preparation of these materials, the different methods of synthesizing and summarizing the most promising results in their use in MRI, magnetic hyperthermia and other emerging applications in the field of nanomedicine

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Summary

Introduction

The field of nanotechnology has exploited the improved novel physical, chemical and biological properties of materials at the nanometric scale. The use of engineered nanomaterials promotes the development of new highly effective methods for diagnostics and cancer therapy [2] Within this framework, magnetic nanoparticles (MNPs) play an important role because of their unique characteristics and properties [3]. A suitable amount of an addition of zinc, manganese, cobalt or nickel to the ferrite nucleus of the NPs results in a higher magnetic resonance imaging contrast and an increase of saturation magnetization (Ms), which can lead to more efficient magnetic targeting [8]. This review will focus on the applications of Mn-Zn ferrite NPs in biomedical applications, by covering the most important aspects of the preparation of these materials, the different methods of synthesizing and summarizing the most promising results in their use in MRI, magnetic hyperthermia and other emerging applications in the field of nanomedicine

Synthetic Strategies of Mn-Zn Ferrites
Co-Precipitation Method
Thermal Decomposition Method
Microemulsion Method
Hydrothermal Method
Sol-Gel Method
In Vivo Applications of Mn-Zn Ferrites
Findings
Perspectives
Full Text
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