Abstract
Insufficient efficiency and safety of cellular probiotics encourages the search for new effective means of correction of microecological disorders. Most of the beneficial effects of probiotics are due to the biological activity of their structural components and metabolites. Recently, great hope is pinned on postbiotic products as a means of restoring the balance of intestinal microbial populations. The data obtained in this experimental study demonstrate the ability of cell-free extracts from Bifidobacterium bifidum 1 and Lactobacillus reuteri DSM 17938 cultures, cultivated in their own disintegrates supplemented with ascorbic acid, to provide anti-infection protection and correct microecological disturbances at modeling an infectious process against a background of antibiotic-induced dysbiosis in mice. The beneficial effects of cell-free extracts showed up in the acceleration of the pathogen elimination and an increase in the number of representatives of the positive intestinal microbiota. The results of the study justify the need for further clinical trials to determine the therapeutic efficacy of cell-free extracts when included in the protocols of dysbiosis treatment.
Highlights
Insufficient efficiency and safety of cellular probiotics encourages the search for new effective means of correction of microecological disorders
Отримані на 2-у добу після закінчення введення гентаміцину результати бактеріологічного дослідження фекалій свідчили про розвиток дисбактеріозу кишечника у мишей
Порівняно з групою позитивного контролю у тварин дослідних груп, які перорально отримували безклітинних екстрактів (БКЕ) МВА та MLA, спостерігалося достовірно менше зниження маси тіла в критичні перші дні інфекційного процесу, не спостерігалося змін поведінки та консистенції фекальних мас
Summary
Knysh Oksana, Senior researcher, Mechnikov Institute of Microbiology and Immunology of the National Academy of Medical Sciences of Ukraine, laboratory of respiratory infections prevention, Ukraine, Kharkiv, ORCID ID: https://orcid.org/0000-0002-4105-1299 Pogorila Marina, Senior researcher, Mechnikov Institute of Microbiology and Immunology of the National Academy of Medical Sciences of Ukraine, laboratory and clinical department of molecular immunopharmacology, Ukraine, Kharkiv, ORCID ID: https://orcid.org/0000-0002-1783-9772 Polianska Valentina, Assistant Professor, Ukrainian Medical Stomatological Academy, microbiology, virology and immunology department, Ukraine, Poltava, ORCID ID: https://orcid.org/0000-0002-8727-9029 Zachepylo Svitlana, Assistant Professor, Ukrainian Medical Stomatological Academy, otorhinolaryngology with ophthalmology department, Ukraine, Poltava, ORCID ID: https://orcid.org/0000-0002-2194-0611
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