Application Effect and Evaluation of Two-Dimensional Speckle Tracking Imaging on Myocardial Damage in Patients with Malignant Lymphoma Treated with Anthracyclines.

Chunqiang Bai,Liang Fang,Qiankun Chang,Fanyue Meng,Peiming Feng,Wan Wang,Lihong Wang

doi:10.1155/2021/6355047

Abstract

Objective The purpose was to study the monitoring effect and application value of two-dimensional speckle tracking imaging (2D-STI) on myocardial function in patients with malignant lymphoma after treatment with anthracyclines. Methods 50 patients with malignant lymphoma treated in our hospital from June 2017 to December 2019 were randomly selected and were treated with anthracyclines to compare the cardiac global longitudinal strain (GLS), global radial strain (GRS), global circumferential strain (GCS), left ventricular twist (LVtw), GLS × LVtw, and changes of atrioventricular inner diameters before and after 3 cycles of treatment. According to the pathological examination results, the accuracy of 2D-STI in the detection of changes in myocardial function of patients was also clarified. Results The absolute values of GLS, GRS and GCS after treatment were significantly lower than those before treatment, with statistical significance (P < 0.05). The LVtw and GLS × LVtw after 3 cycles of treatment were significantly lower than those before treatment, with statistical significance (P < 0.05). There was no significant difference in the atrioventricular inner diameters of patients before and after treatment, with no statistical significance (P > 0.05). There was no significant difference between the monitoring results of 2D-STI and the pathological examination results, with no statistical significance (P > 0.05). Conclusion Anthracyclines can cause some myocardial damage in patients with malignant lymphoma. The application of 2D-STI to monitor the changes in myocardial function of patients can give more accurate monitoring results, facilitating the early implementation of appropriate treatment.

Highlights

As a common malignant tumor with high mortality and high recurrence rate, malignant lymphoma mainly occurs in lymph nodes or lymphatic tissue outside lymph nodes, and patients with malignant lymphoma need timely treatment after diagnosis [1,2,3]
All patients received chemotherapy with anthracyclines, for 21 days as one cycle. 2D-STI was used to detect the myocardial function of the patients before and after 3 cycles of chemotherapy, respectively, and to observe whether there was myocardial damage during treatment. e 2D-STI examination was performed by the same group of high-calibre ultrasound doctors using the same ultrasound diagnostic apparatus. e Philips digital high-grade cardiac color Doppler ultrasound diagnostic apparatus was used for detection, with the probe frequency of 3.0–7.0 MHz
QLAB software was used to detect and analyze the cardiac global longitudinal strain (GLS), global radial strain (GRS), global circumferential strain (GCS), left ventricular twist (LVtw), and GLS × LVtw. e atrioventricular inner diameters were directly reflected in the 2D-STI results, and the accuracy of 2D-STI was obtained after the 2D-STI results were compared with the pathological examination results

Summary

Introduction

As a common malignant tumor with high mortality and high recurrence rate, malignant lymphoma mainly occurs in lymph nodes or lymphatic tissue outside lymph nodes, and patients with malignant lymphoma need timely treatment after diagnosis [1,2,3]. Electrocardiogram, ultrasound, MRI, and blood index examination are commonly used in the Evidence-Based Complementary and Alternative Medicine diagnosis and detection of myocardial damage caused by anthracyclines. It has been applied to evaluate the cardiac function of many heart diseases and is more sensitive than conventional ultrasound examination. It has been used for the detection of cardiotoxicity induced by chemotherapy drugs and for the development of advanced cardiotoxicity prediction studies. Patients with malignant lymphoma treated with anthracyclines were selected as research subjects to analyze the application value of 2D-STI in detecting the degree of myocardial damage in patients, reported as follows

Methods

Results

Conclusion