Abstract
Deoxyribonucleic acid (DNA) is the hereditary material in humans and almost all other organisms that carry hereditary information are made of chemical building blocks called nucleotides. Over the 50 years of research, the drug researchers have made a conclusion that the interaction between DNA and small molecules helps to understand the action mechanism of DNA-targeted drugs and toxic agents and also some diseases such as gene mutation. In order to develop new drugs which target specifically to DNA, it is necessary to understand the modes of binding. DNA provides a range of binding sites that trigger the modes of binding. The intercalative mode of binding is the most effective for drug targeting DNA that relates to antitumor activity. The DNA affinity and binding selectivity depend upon the size and shape of metal complexes coordinated to the same ligand.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
