Abstract
In recent years, monolithic supports as stationary phases in high-performance liquid chromatography (HPLC) have become a rapidly burgeoning field. This review summarizes the current achievements and their application in pharmaceutical analysis and separation. One kind is the silica monoliths prepared from tetraalkoxysilane by a sol-gel method with either micrometer-size through-pores or high specific surface areas and well suited for small molecules in HPLC modes. The other kind is the organic polymer-based monoliths including monolithic molecularly imprinted polymers in treatments of the samples before injected into the chromatograph in biological fluids. The analytical potential of these columns is demonstrated with separations involving various drugs in different chromatographic modes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
