Abstract
Use of the third-generation, thyroid-stimulating hormone (TSH) assay in gravid patients has not been validated. We obtained serum from 93 healthy women with a singleton gestation and measured TSH using a two-site immunochemiluminescent (“sandwich”) assay. Standard immunoassays were employed for total T4, free T4, and T3 levels. Reference ranges (RR) established by the kit manufacturer were used for comparison. Although the mean TSH level for our population was within the RR, 12/93 women (13%) had a TSH value below the lower limit of normal. None, however, had clinical hyperthyroidism or an elevated free T4. Established RR for the third-generation TSH assay may not apply to pregnant women, and isolated TSH measurements during pregnancy should be interpreted with caution.
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