Abstract
Urine specimens from patients on chlorpromazine therapy, frozen in batches from 750 to 4000 ml, were slowly thawed at refrigerator temperatures of 5–8° C. Aliquots of increasing volumes were collected sequentially for determinations of comjugated and unconjugated drug fractions. From 9 to 15 fold concentration of the drug content was obtained in the initial 1 2 % of collected volumes, and from 50 to 60% of the drug metabolites were recovered in 10 to 12% of the original volumes. The procedure therefore lends itself to a variety of purposes concerned with concentration and isolation of chlorpromazine drug metabolites.
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