Abstract
Water-deprived rats were trained and extinguished on a lever-press response for water. Injection of 12 IU of ACTH in saline one-half hour prior to acquisition sessions increased responding early in extinction. Exogenous ACTH prior to extinction sessions had no effect on response rates. Acquisition performance with ACTH injections was examined in a second experiment utilizing more stringent controls for extraneous noise and level of motivation. In this study injection of 10 IU of ACTH prior to the session led to a highly significant increase ( p < 0.001) in the number of lever-press responses per session late in training. These findings show that pituitary-adrenal hormones may play a role in adaptive behavior which is not restricted to acutely aversive situations.
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