Abstract
To determine the optimal conditions for collecting unidentified cells, named alginate-induced reddish purple-stained cells (ARPC), sodium alginate, a heteropolyuronate derived from brown algae, was injected intraperitoneally. In the present study it was investigated if sodium alginate induced cell accumulation in the mammalian mouse peritoneal cavity. Intraperitoneal injection of sodium alginate in ddY mice resulted in great accumulation of cells that were stained reddish purple with Wright/Giemsa, together with leukocytes including neutrophils, macrophages and lymphocytes. Accumulation of the alginate-induced reddish purple-stained cells (AR1PC) was found to be maximam at a dose of 10 mg/mouse. This phenomenon was not strain-specific but also observed in ICR, C57BL/6, AKR/J and BALB/c mice. Intraperitoneal injection of sodium alginate solution containing the optimal dose (10 mg/animal) induced accumulation of ARPC in mice.
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