Abstract
Activities of energy conservation system in rat liver mitochondria during development were examined before and after birth. Both the respiratory control and the energy-dependent H+-efflux were extremely lower in fetal mitochondria than in adult ones. The high concentration of exogenous ADP or ATP+Mg2+ increased the energy conservation activity in fetal mitochondria, with the increase in the AdN* contents. AdN contents in mitochondria increased in parallel with the respiratory control after birth, but the Pi content changed only slightly at birth. The atractyloside-sensitive uptake of [14C]AdN into mitochondria was low in fetus and increased after birth. The uptake of ATP was dependent on the concentration of exogenous ATP.
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