Abstract
This study was conducted to investigate the influence of Mib-1 index on outcome in 55 patients with T1-4 anal carcinomas treated radically by radiotherapy (RT) alone (24) or by concomitant chemo-radiotherapy (31). Median follow-up for surviving patients was 94 months (range 17-179 months). Tissue materials were obtained from pretreatment biopsies. A modified immunoperoxidase technique consisting of microwave heating of routinely processed material was employed using the Mib-1 antibody (Immunotech, 1:50). The median Mib-1 index for all patients was 53% (range 18-96%). Subgroups of patients with high vs low Mib-1 indices (separated by the median value) had statistically similar outcomes regarding 5-year overall survival (64% vs 65% P = 0.7), locoregional control (77% vs 69%, P = 0.5) and disease-free survival (73% vs 66%, P = 0.5). Moreover, no significant association was found between mean Mib-1 indices and various clinicopathological parameters studied (age, sex, circumferential tumour extent, T-stage, N-stage and histological type). In conclusion, Mib-1 index failed to predict the outcome of patients with anal carcinomas treated conservatively by radiotherapy with or without chemotherapy. It is noteworthy that the median Mib-1 index observed in anal carcinomas in this study was among the highest yet reported for cancers of epithelial origin.
Highlights
The study population consisted of 55 patients with anal carcinoma treated with curative intent at the University Hospital of Geneva between March 1976 and July 1993, for whom adequate paraffinembedded material had been retrieved for analysis
Pinder et al (1995), in a series of 177 patients with breast carcinoma, found the Mib-1 index to be strongly associated with histological grade, tumour size and patient survival (P = 0.001), and to be significantly correlated with survival in a multivariate analysis
Inconclusive or contradictory results have been reported for certain other tumour types, namely oesophageal squamous cell carcinomas (Youssef et al, 1995; Sarbia et al, 1996), gastric carcinomas (Yonemura et al, 1991; Muller et al, 1996) and lung carcinomas (Pence et al, 1993; Pujol et al, 1996), and several studies showed no predictive value of the Ki-67 index in cervical carcinomas (Cole et al, 1992; Levine et al, 1995; Oka and Arai, 1996)
Summary
The study population consisted of 55 patients with anal carcinoma treated with curative intent at the University Hospital of Geneva between March 1976 and July 1993, for whom adequate paraffinembedded material had been retrieved for analysis.
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