Apparent diffusion coefficient histogram analysis for differentiating fibroblastic meningiomas from non-fibroblastic WHO grade 1 meningiomas

Abstract

PurposeTo investigate the role of apparent diffusion coefficient (ADC) histogram analysis in differentiating fibroblastic meningiomas (FM) from non-fibroblastic WHO grade 1 meningiomas (nFM). MethodsThis retrospective study analyzed the histopathological and diagnostic imaging data of 220 patients with histopathologically confirmed FM and nFM. The whole tumors were delineated on axial ADC images, and histogram parameters (mean, variance, skewness, kurtosis, as well as the 1st, 10th, 50th, 90th, and 99th percentile ADC [ADCp1, ADCp10, ADCp50, ADCp90, and ADCp99, respectively]) were obtained. Multivariate logistic regression analysis was used to identify the most valuable variables for discriminating FM from nFM WHO grade 1 meningiomas, and their diagnostic efficacy in differentiating FM from nFM before surgery was assessed using receiver operating characteristic (ROC) curves. ResultsThe mean, variance, ADCp50, ADCp90, and ADCp99 of the FM group were all lower than those of the nFM group (P < 0.05), there was significant difference in location and sex (P < 0.05). Multivariate logistic regression showed ADCp99 (P < 0.001) and location (P = 0.007) were the most valuable parameters in the discrimination of FM and nFM WHO grade 1 meningiomas. The diagnostic efficacy was achieved an AUC of 0.817(95% CI, 0.759–0.866), the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were 66.4%, 83.6%, 75.0%, 80.2%, and 71.3%, respectively. ConclusionADC histogram analysis is helpful in noninvasive differentiation of FM and nFM WHO grade 1 meningiomas, and combined ADCp99 and location have the best diagnostic efficacy.