Abstract
BackgroundThe potential of apparent diffusion coefficient (ADC) value alteration before and after chemoradiotherapy as a potential monitor for therapeutic efficiency of treatment for brain metastases from lung cancer were discussed.MethodThirty lung cancer patients with brain metastases, conventional magnetic resonance imaging (MRI) examination and diffusion weighted imaging (DWI) were performed one week before chemoradiotherapy and after one treatment cycle and two treatment cycles. 43 tumor lesions were divided into effective group and invalid group according to the changes of the tumor size. The differences in ADC values at different time points before and after treatment in each treatment group were analyzed.ResultThe maximum diameter of the tumor was no difference after one treatment cycle, but decreased after two treatment cycles. ADC values significantly increased after both one and two treatment cycles. In effective group, the ADC values were significantly increased after one and two treatment cycles. While, there are no difference in invalid group after one treatment cycle but decreased after two treatment cycles. ΔADC values in effective group after one and two treatment cycles were both significantly higher than those in the invalid group. ROC curve analysis then revealed that the area under the curve (AUC) of ΔADC after one treatment was 0.872.ConclusionADC values in brain metastases from lung cancer can help monitor and dynamically observe the therapeutic efficiency of whole brain chemoradiotherapy.
Highlights
The potential of apparent diffusion coefficient (ADC) value alteration before and after chemoradiotherapy as a potential monitor for therapeutic efficiency of treatment for brain metastases from lung cancer were discussed
Cumulative incidence of brain metastases is noted to be high for patients with locally advanced lung cancer and HER2 positive metastatic breast cancer, with figures of up to 30–60% reported [3,4,5]
Diffusion-weighted magnetic resonance (MR) imaging detects the water mobility to reflect the morphologic and physiologic changes in tissues which was wildly applied in chest tumors characterization [9, 10]. tThe apparent diffusion coefficient (ADC) of the lesion but these readings have more recently been suggested to have some prognostic value as well as diagnostic in brain metastases cancers [11, 12]
Summary
The potential of apparent diffusion coefficient (ADC) value alteration before and after chemoradiotherapy as a potential monitor for therapeutic efficiency of treatment for brain metastases from lung cancer were discussed. Magnetic resonance imaging (MRI) has been regarded as a gold standard for detection of brain. Liu et al BMC Medical Imaging (2018) 18:30 metastases from lung cancer, the changes of the tumor size exist significantly behind changes in biological and molecular levels. Diffusion-weighted magnetic resonance (MR) imaging detects the water mobility to reflect the morphologic and physiologic changes in tissues which was wildly applied in chest tumors characterization [9, 10]. TThe apparent diffusion coefficient (ADC) of the lesion but these readings have more recently been suggested to have some prognostic value as well as diagnostic in brain metastases cancers [11, 12]. The efficiency of the ADC values as an index of brain metastases, and its advantages over MRI remain controversial
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