Abstract

Abstract A new apparatus has been designed to assess rates of disintegration of tablet coatings and the availability of coated tablet contents. Random movement of the coated tablet in a known volume of mildly turbulent disintegrating fluid at a standard temperature is achieved in a perforated Perspex drum made to revolve slowly in the fluid which moves up and down in its container at the same time. The procedure eliminates the tendency for coatings to stick together or to the grid during a test, which is seen with present pharmacopoeial designs and which causes large variability in the results.

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