Abstract
Polymer-supported library compounds have been cleaved from acid sensitive linkers using gaseous reagents hydrogen fluoride and hydrogen chloride. Compounds attached to Wang, Rink, AMEBA, and MBHA linkers were cleaved. The reaction gas container for gaseous cleavage was made of a polypropylene tube enclosed by two side-plates. Fast and reliable filling by a reagent gas was achieved by introducing the gas into the evacuated reaction container rather than gradually replacing the gas under atmospheric pressure.
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