Abstract
Apoptotic cell clearance and its role in the origin and resolution of chronic inflammation.
Highlights
Besides the autoimmune phenotype of chronic inflammatory rheumatoid disorders, a plethora of pathologies have been associated with defects in genes involved in the clearance of cell remnants from tissues [3, 4]
This Research Topic bundles a set of manuscripts describing various ways of how such “uncleared” cell remnants participate in the pathogenesis of chronic inflammatory diseases and cancer
González and Hidalgo emphasize that it is possible to take advantage of the huge amount of published evidence on therapeutic modulation of the liver X receptor activity in clearance-associated diseases [6]. Pharmacological regulation of such nuclear factors, which are activated upon recognition of dying cells, may enhance the ability of macrophages to clear dead cells and thereby provide additional beneficial effects for treating clearance-related diseases like osteoporosis, rheumatoid arthritis, atherosclerosis, diabetes, and Alzheimer’s disease [7,8,9,10]
Summary
Besides the autoimmune phenotype of chronic inflammatory rheumatoid disorders, a plethora of pathologies have been associated with defects in genes involved in the clearance of cell remnants from tissues [3, 4]. This Research Topic bundles a set of manuscripts describing various ways of how such “uncleared” cell remnants participate in the pathogenesis of chronic inflammatory diseases and cancer. González and Hidalgo emphasize that it is possible to take advantage of the huge amount of published evidence on therapeutic modulation of the liver X receptor activity in clearance-associated diseases [6].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
