Abstract
Transplantation of pancreaticoduodenal allografts in the PVG.RT1c----PVG.RT1u high responder rat strain combination led to the evolution of haemorrhagic pancreatic necrosis over a rejection course of 8d. A cellular infiltrate consisting mainly of monocytes and macrophages was detectable in the stroma while acinar cells showed degranulation and a progressive decrease in number. From day 4 on apoptotic bodies could be identified ultrastructurally within the exocrine tissue. Apoptosis during pancreas rejection, previously undescribed, contributes to acinar cell loss after transplantation in this model.
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Schedule a callMore From: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
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