Abstract
Eosinophils have crucial role in allergic inflammation and asthma. Prolong survival and pathological accumulation at the site of inflammation exclusively related to destructive activity of these pathogenic granulocytes by releasing tissue toxic and inflammatory granule proteins. Any deficiency in eosinophil apoptosis may put in to condition of eosinophilia. Thus, removal of eosinophils by inducing apoptosis has been proposed as potential anti inflammatory strategy in eosinophilia. Apoptosis proves to be beneficial for development of future airway drugs. For therapeutic instances, many reviews illustrate the importance of glucocorticoids as potent anti-inflammatory agent and known to induce apoptosis in eosinophils. Apart from glucocorticoids, theophylline and histamine are well studied apoptosis inducing agents in eosinophil related inflammation. This review elaborates the anti-inflammatory characters of apoptosis in asthma and allergic inflammation.
Highlights
Eosinophilia is a provision in which peculiarly elevated amounts of eosinophils are found in either blood or in tissues and their number exceed from 600 cells per micro liter (μ L) of blood
Throughout the progression of apoptosis, all the active cellular contents are remained enclosed by cell membrane since it is a typical pathway through which malfunctioning and dangerous materials are eliminated without causing impairment to the body like necrosis [2]
It has been reported that dysregulated apoptosis can escort to pathological accumulation of eosinophils in bronchial tissue grounding allergic diseases such as asthma
Summary
Muhammad Qasim1*, Rizwan Abid, Mahmood-ur-Rahman, Muhammad S Masoud, Usman A Ashfaq1 1Department of Bioinformatics and Biotechnology, Government College University Faisalabad (GCUF), Paki stan 2Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, Pakistan
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