Apomorphine markedly potentiates naltrexone-induced hypodipsia in the rat

Abstract

This article describes the effects of apomorphine on naltrexone-induced decreases in water intake of the rat deprived of water for 24 h. Apomorphine alone at reasonable doses (0.03, 0.1, 0.3 and 1.0 mg/kg) failed to affect water intake of the rat, but a higher dose (3.0 mg/kg) abolished water intake completely, accompanied by marked stereotypy. Naltrexone (0.1, 1.0 and 10.0 mg/kg) produced a dose-dependent reduction in water intake. A 0.3-mg/kg dose of apomorphine which is considered to activate preferentially presynaptic dopamine autoreceptors enhanced markedly naltrexone (1.0 and 10.0 mg/kg)-induced decreases in water intake. Only apomorphine at 1.0 mg/kg caused a significant prolongation of the latency to start drinking. Apomorphine (0.3 mg/kg), naltrexone (0.1, 1.0 and 10.0 mg/kg) or their combinations did not produce a marked effect on locomotor activity in the rat. These results suggest that apomorphine is capable of potentiating naltrexone-induced decreases in water intake through the mediation of presynaptic dopamine autoreceptors without causing motor dysfunction.