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Abstract
(1) Five female in-patients suffering from anorexia nervosa of moderate-severe degree were given the dopamine receptor agonist apomorphine. The growth hormone (GH) secretion induced by this stimulation was measured and the results compared with those of age-matched healthy female controls. (2) In contrast to most previous reports we failed to demonstrate elevated basal levels of GH in the anorectic group compared to the controls. (3) None of the anorectic patients showed any increase in GH values after apomorphine compared to 5 out of 9 controls. It is concluded that the failure to respond is not dependent on a high basal level of GH. (4) Our results lend support to the notion that there may be some abnormality in hypothalamic function possible involving dopamin receptor activity in anorexia nervosa.Jan Wglinder, M.D., Ph.D., Professor, Department of Psychiatry, University Hospital, University of Linkoping, S-581 85 Linkoping SwedenJan Balldin, M.D., Ph.D., Consultant, Department of Psychiatry and neuroch...
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