Abstract
To clarify the role of apolipoprotein E (apoE) in the pathophysiology of Alzheimer's disease (AD), we used an RT-PCR method to investigate apoE and glial fibrillary acidic protein (GFAP) mRNA expression in the brain. ApoE mRNA was significantly more abundant in AD (0.379 ± 0.191, mean ± SD) than in control (0.125 ± 0.073, p < 0.05) brain tissue, but in AD it was decreased in relation to the apoE-ϵ4 gene dosage. The GFAP mRNA content also was greater in AD (5.96 ± 2.94) than in control (3.80 ± 2.78) tissue, and in AD showed an increase relative to the apoE-ϵ4 gene dosage. AD patients who had long survival times showed high expression of apoE and low expression of GFAP. These results suggest that apoE suppresses the progression of AD, including gliosis, in the brain.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
