Apolipoprotein A-I/B Ratios May Be Useful in Coronary Heart Disease Risk Assessment

Abstract

Henry O. Ogedegbe, PhD, BB(ASCP)SC Department of Environmental Health, Molecular and Clinical Sciences, Florida Gulf Coast University, Fort Myers, FL anti-factor Xa of 0.20 U/mL with a range of 0.01 to 1.00 U/mL. The average bias for these 54 paired samples was 0.01 U/mL, indicating no meaningful effect of the pneumatic tube delivery on anti-factor Xa measurements. As shown in T2, the 37 rapid, higher speed centrifugation comparison samples had a median anti-factor Xa of 0.17 U/mL with a range of 0.01 to 0.89 U/mL. The average bias for these 37 paired samples was 0.00 U/mL, indicating no meaningful effect of rapid, higher speed centrifugation on anti-factor Xa measurements. Discussion The anti-factor Xa assay is sensitive to the release of the heparin neutralizing substance platelet factor 4 from normal blood platelets.2 Although several previous studies of pneumatic tube delivery and rapid, higher-speed centrifugation did not detect effects on platelet counts, coagulation factor levels, prothrombin times, activated partial thromboplastin times, or fibrinogen concentrations,6,7 we found no reports studying the anti-factor Xa assay. Neither pneumatic tube delivery nor rapid, higher-speed centrifugation caused a detectable effect on the antifactor Xa assay in this study. These technologies speed coagulation laboratory work and appear to be acceptable for chromogenic anti-factor Xa assay monitoring of heparin therapy.