Abstract
BackgroundThe study was designed to investigate lipid profile and SYNTAX score in patients with non-ST segment elevation myocardial infarction (NSTEMI).Methods311 patients with NSTEMI were enrolled. The demographic, clinical data, blood samples and SYNTAX score were documented. The Pearson linear correlation was used to detect confounding factors linearly correlated with SYNTAX score. The significantly correlated confounding factors were put into the multiple linear regressions.ResultsThe Pearson linear correlation showed that high-density lipoprotein- cholesterol (HDL-C) and apolipoprotein A1 (ApoA1) were significantly correlated with Syntax Score (r = − 0.119, P = 0.044 and r = − 0.182, P = 0.002, respectively). The multiple linear regressions for Syntax Score were built using HDL-C and ApoA1, respectively. After the adjustment of other significantly correlated confounding factors such as white blood cell count (WBC), myohemoglobin (MB), glutamic-oxalacetic transaminase (AST) and creatinine, the ApoA1 still showed significant association with Syntax Score (β = − 0.151, P = 0.028). The area under curve was (AUC) 0.624 and the optimal cutoff value is 1.07 g/L when using ApoA1 to predict moderate and severe coronary artery lesions. The patients with ApoA1 ≥ 1.07 g/L and < 1.07 g/L have the Syntax Scores of 12.21 ± 11.58 and 16.33 ± 11.53, respectively (P = 0.001).ConclusionsThe ApoA1 is the only lipid factor significantly associated with complexity of coronary artery lesion in patients with NSTEMI, the patients with ApoA1 < 1.07 g/L may have more complex coronary artery lesions.
Highlights
The study was designed to investigate lipid profile and SYNTAX score in patients with non-ST segment elevation myocardial infarction (NSTEMI)
The present study intended to investigate the association between lipids factors and SYNTAX score in NSTEMI patients
Myocardial enzyme changes include significant elevation of creatine kinase (CK), creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), Troponin I, myoglobin (MB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) or transglutaminase according to features and occurrence time of each enzyme in NSTEMI patients
Summary
The study was designed to investigate lipid profile and SYNTAX score in patients with non-ST segment elevation myocardial infarction (NSTEMI). Non-ST segment elevation myocardial infarction (NSTEMI) is one of the most severe and lethal form of myocardial infarction [1, 2]. Apolipoprotein A1 (ApoA1), the main protein component of HDL-C in the plasma has functions of. Apolipoprotein B (ApoB) is the main component of LDL-C, and its level could reflect the level of atherogenic lipoprotein particles [12, 13]. A previous study has investigated the association between the lipids factors and SYNTAX score in patients with stable coronary artery disease [14]. The present study intended to investigate the association between lipids factors and SYNTAX score in NSTEMI patients
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