Abstract
We have recently reportd that apolipoprotein A-IV (apo A-IV), a protein associated with lipoproteins, acts in the brain to inhibit gastric acid secretion. In the present study, we determined whether or not apo A-IV has an anti-ulcer action via the central nervous system using Sprague-Dawley rats. Intracisternal injection of apo A-IV dose-dependently (2.0–4.0 μg/rat) reduced the severity of gastric mucosal lesions induced by intravenous injection of 2-deoxy- d-glucose or subcutaneous administration of indomethacine. A higher dose (15 μg) of apo A-IV injected intraperitoneally failed to inhibit the development of gastric mucosal damage evoked by these ulcerogenic agents. These results suggest for the first time that apo A-IV has an anti-ulcer action through a central mechanism.
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