Abstract
BackgroundWe sought to examine whether ε4 carrier status modifies the relation between body mass index (BMI) and HDL. The National Heart, Lung, and Blood Institute Family Heart Study included 657 families with high family risk scores for coronary heart disease and 588 randomly selected families of probands in the Framingham, Atherosclerosis Risk in Communities, and Utah Family Health Tree studies. We selected 1402 subjects who had ε4 carrier status available. We used generalized estimating equations to examine the interaction between BMI and ε4 allele carrier status on HDL after adjusting for age, gender, smoking, alcohol intake, mono- and poly-unsaturated fat intake, exercise, comorbidities, LDL, and family cluster.ResultsThe mean (standard deviation) age of included subjects was 56.4(11.0) years and 47% were male. Adjusted means of HDL for normal, overweight, and obese BMI categories were 51.2(± 0.97), 45.0(± 0.75), and 41.6(± 0.93), respectively, among 397 ε4 carriers (p for trend < 0.0001) and 53.6(± 0.62), 51.3(± 0.49), and 45.0(± 0.62), respectively, among 1005 non-carriers of the ε4 allele (p-value for trend < 0.0001). There was no evidence for an interaction between BMI and ε4 status on HDL(p-value 0.39).ConclusionOur findings do not support an interaction between ε4 allele status and BMI on HDL.
Highlights
HDL cholesterol (HDL) has been associated with lower risk of coronary heart disease (CHD) in observational and trial cohorts [1,2,3,4,5,6,7,8]
To the best of our knowledge, no researchers have reported whether Apolipoprotein E (APOE) ε4 allele carrier status modifies the relation between higher body mass index (BMI) and lower HDL levels in a cohort enriched with subjects and higher-than-average risk for CHD
To evaluate whether there is a significant interaction between BMI and APOE ε4 carrier status on HDL levels, we examined the relationship between these in a cohort of 1402 men and women selected from the National Heart, Lung, and Blood Institute Family Heart Study (NHLBI FHS)
Summary
HDL cholesterol (HDL) has been associated with lower risk of coronary heart disease (CHD) in observational and trial cohorts [1,2,3,4,5,6,7,8]. To the best of our knowledge, no researchers have reported whether APOE ε4 allele carrier status modifies the relation between higher BMI and lower HDL levels in a cohort enriched with subjects and higher-than-average risk for CHD. This question may be important from a clinical standpoint, to determine whether carriers of Apo ε4 are at any disadvantage when attempting to lower their BMI to achieve a more favorable lipid profile. We used generalized estimating equations to examine the interaction between BMI and ε4 allele carrier status on HDL after adjusting for age, gender, smoking, alcohol intake, mono- and poly-unsaturated fat intake, exercise, comorbidities, LDL, and family cluster
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