Abstract
Normal-Weight Obesity Syndrome has been characterized by a normal body mass index and high percentage of body fat. It is associated with an increased risk of cardiovascular disease development. This study aimed to evaluate whether apolipoprotein E (APOE) genotypes and food consumption are related to the lipid profiles of adults with Normal-Weight Obesity Syndrome. Analytical cross-sectional study, including adults with Normal-Weight Obesity Syndrome. Socioeconomic, health and lifestyle questionnaires were administered. Anthropometric variables, body composition and blood pressure were evaluated. Dietary intake, lipid profile and genotyping of polymorphisms rs7412 and rs429358 in the APOE gene were evaluated. Only 6.0% of women and none of the men had increased waist circumference (≥80cm for women and ≥94cm for men). No women and 6.2% of men had altered blood pressure (systolic blood pressure ≥130mmHg and/or diastolic blood pressure ≥85mmHg). When the traditional lipid profile was assessed, 52.5% of individuals presented dyslipidaemia. When the levels of apolipoproteins A1 and B were included, the prevalence was 73.0%. Regression analysis showed a positive relationship between the presence of allele ε2 and apolipoprotein A1 levels (95% CI=4.2 to 38.3; p=0.015) and between the ε4 allele and apolipoprotein B (ε4 versus ε2: 95% CI=0.08 to 29.5; p=0.049 and ε4 versus ε3: 95% CI=0.6 to 17.6; p=0.036). Carriers of the ε2 allele had a 75.0% lower probability of presenting dyslipidaemia compared with ε3ε3 individuals (95% CI=0.04 to 0.8; p=0.027). Relationships between body fat, food consumption and lipid profile were observed and differed among genotypes. APOE genotype and food consumption were associated with lipid profile. This was the first study to evaluate the APOE genotype and to analyze relationships between genetic profile, food intake and lipid profile of subjects with Normal-Weight Obesity Syndrome.
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