Abstract
Small intraperitoneal doses of apocodeine (APC) increased spontaneous penile erection (PE) in adult rats, in a direct dose-related manner for doses up to 50 μg·kg −1, larger doses being progressively less active. Intraperitoneal APC evoked stereotyped behaviour (SB) only if given at dosages of 10 mg·kg −1 or more, SB being never very severe even then. Thus, APC was as active as apomorphine (APM) in inducing PE, but less active in inducing SB. The oral administration of APC also induced PE but did not induce SB, whatever the dose. In this, APC resembled APM, and similarly its effect on PE was prevented by haloperidol. The influence exerted by APC on the spontaneous PE of the rats seems to be directly related to its effect on the CNS because of the significantly increased capacity of the intraventricularly injected drug. In conclusion, the behavioral effects induced by APC in rats are very similar to those produced by APM, the mechanism of action for both drugs involving central dopamine receptors. The neural mechanisms causing PE and SB appear to be incompatible.
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