Apnea Hypopnea Index, Oxygen Desaturation Index, and QTC Interval in Obstructive Sleep Apnea

Abstract

SESSION TITLE: Sleep Disorders Posters II: Consequences of OSA and Treatment SESSION TYPE: Original Investigation Poster PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM PURPOSE: Obstructive Sleep Apnea is associated with an increased cardiovascular risk, including cardiac arrhythmias. Apnea Hypopnea Index (AHI) and /or Oxygen Desaturation Index (ODI) may be associated with QTc interval abnormalities in patients with OSA. The aim of this study is to assess the correlations between ODI, AHI and QTc values in patients with OSA. METHODS: In patients with OSA (ambulatory cardio-respiratory polygraphy with AHI>5/hour), a resting 12 channels ECG was performed. Anthropometric indices, ODI, AHI, nocturnal oxyhaemoglobin levels (average and lowest SaO2), corrected QT intervals (QTc; Bazett's formula) and the correlations between them were analyzed in patients with sinus rhythm. RESULTS: 98 patients meet the inclusion criteria, 5 had atrial fibrillation and were excluded. The remaining 93 patients (70 men) had a median age of 58 years (24-79), a median BMI: 32,4 Kg/m2 (22,0-64,4) and a median AHI: 34/hour (5-107). The median ODI 3% was 24/hour (2-105), median average SaO2: 93% (76-97) and median lowest SaO2: 79% (24-91). The mean QTc value was 422,8±27,15 ms. A strong positive correlation between AHI and ODI 3% was found (r: 0.81, p<0,0001). Statistically significant correlations between QTc and ODI 3% (r: 0,29, p: 0,004), average SaO2 (r :-0,26 p :0,01), lowest SaO2 (r :-0,25 P :0,01) and AHI (r: 0,21, p : 0,04) have been identified. ODI and nocturnal oxyhaemoglobin levels correlate better <span style="line-height:20.7999992370605px">than AHI </span>with <span style="line-height:20.7999992370605px">QTc</span> in patients with OSA. CONCLUSIONS: Oxygen Desaturation Index and nocturnal oxyhaemoglobin levels may be more appropriate than AHI in assessing the existence of QTc abnormalities in OSA patients. CLINICAL IMPLICATIONS: Overnight pulseoxymetry may be useful in assessing the risk of cardiac arrhythmias in sleep apnea. DISCLOSURE: The following authors have nothing to disclose: Stefan Dumitrache-Rujinski, Ionela Erhan, Alexandru Cocieru, Ionela Butuc-Andreescu, Alexandru Muntean, Dragos Zaharia, Claudia Toma, Miron Bogdan No Product/Research Disclosure Information