Abstract
OBJECTIVE: The pathogenesis of endometriosis is still controversial, however, local inflammatory reaction in the peritoneal environment is considered one of the contributing factors. We previously showed that tumor necrosis factor(TNF)-α enhanced proliferation of endometriotic stromal cells (ESCs) via inducing interleukin (IL)-8 expression. It has been reported that increased PGE2 levels in the peritoneal fluid of women with endometriosis, and that COX-2 regulates survival and invasion of ESCs. Apigenin is a member of flavone subclass of flavonoids present in various fruits and vegetables, and is considered to have multiple biological activities such as anti-proliferative, anti-inflammatory and free-radical scavenging properties.
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