Apelin as a potential marker in Iraqi children with Type 1 Diabetes Mellitus

Abstract

Objective: This study aims to evaluate apelin levels and their correlation with key metabolic parameters in pre-pubertal and pubertalindividuals with type 1 diabetes in Iraq, providing insights into apelin's role in diabetes pathogenesis and its potential as an early diagnostic marker for cardiovascular disease. Methods: Ninety children, divided into pre-pubertal T1DM, pubertal T1DM, and healthy subjects, underwent measurements of variousbiochemical parameters, including apelin, fasting blood glucose, lipid profile, and thyroid hormones. Results: Positive correlations (P < 0.01) were found between apelin levels and FSB, TG, BMI, HbA1c, TC, TSH, and a negative correlation with HDL-C in pubertal and pre-pubertal groups, revealing potential links between apelin, glucose, and insulin sensitivity. Conclusion: The study suggests apelin's involvement in diabetes pathogenesis, highlighting its rise in adulthood as an indicator of diabetes complications and its potential use as a diagnostic marker for early detection of cardiovascular disease in individuals with T1DM.