Abstract
This study was designed to determine the levels of early endothelial progenitor cells (EPCs), apelin, vascular endothelial growth factor (VEGF) and stromal cell-derived growth factor-1 (SDF-1) after acute myocardial infarction (AMI), and to investigate the relationships between these cytokines and early EPCs. Early EPCs, defined as CD133+, KDR+, and CD34+ cells, were quantified by flow cytometry. The levels of early EPCs and those cytokines in AMI patients were significantly different from those with coronary artery disease or controls (P < 0.05). Plasma apelin levels were inversely correlated with Gensini score and early EPCs (both P < 0.01). Early EPCs, VEGF and SDF-1 showed different patterns of changes in AMI patients during the first 24 h. The trend in the change of early EPCs was proportionally correlated with that of VEGF (P < 0.05). AMI patients exhibited increased early EPCs with remarkably decreased apelin levels and enhanced VEGF levels.
Highlights
Endothelial progenitor cells (EPCs) are circulating angioblasts derived from human bone marrow with a potential to differentiate into endothelial cells[1,2]
There were no differences in age, body mass index (BMI), cardiovascular risk factors, and current medications (β-adrenoceptor blockers, calcium channel blockers, and angiotensin-converting enzyme inhibitors or angiotensin receptor blockers) among the control, Coronary artery disease (CAD) and acute myocardial infarction (AMI) groups
Apart from classic risk factors, novel biomarkers have recently received much attention[29] and an extreme plasticity is being attributed to apelin and EPCs
Summary
Endothelial progenitor cells (EPCs) are circulating angioblasts derived from human bone marrow with a potential to differentiate into endothelial cells[1,2]. EPCs and plasma levels of apelin, VEGF
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