Abstract
The syndrome of apathy, whether in the context of neurodegenerative disease, vascular insults, traumatic brain injury, or psychiatric disorders, is increasingly recognized as a common source of significant disability. Further, when present in geriatric depression, degree of apathy predicts poor depression outcome. We previously reported a modest effect of escitalopram treatment on apathy in geriatric depression. This study examined the prevalence of apathy in geriatric depression, the relationship between apathy and disability, and the clinical significance of change in apathy following escitalopram treatment in terms of the effect on disability measures.
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